Biased distribution of repetitive elements: a landmark for neo-Y chromosome evolution in Drosophila miranda

Cytogenet Cell Genet. 2001;93(3-4):228-33. doi: 10.1159/000056988.


It is generally assumed that the sex chromosomes developed from a pair of homologs. Over evolution, the proto-Y chromosome, with a very short differential segment, matured in its final stage into a heterochromatic and, for the most part, genetically eroded Y chromosome. The constraints on the evolution of the proto-Y chromosome have been speculated upon since the sex chromosomes were discovered. Several models have been suggested. Drosophila miranda has proved to be a unique and potent model system to study Y-chromosome evolution. We use selected test genes distributed along the neo-Y chromosome as entry gates to analyze the molecular mechanisms involved in the process of Y-chromosome evolution. Here, we report our findings on the Krüppel gene (Kr), which is located distally on the neo-sex chromosome pair.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics*
  • Drosophila / genetics*
  • Drosophila Proteins
  • Drosophila melanogaster / genetics
  • Evolution, Molecular*
  • Female
  • In Situ Hybridization
  • Kruppel-Like Transcription Factors
  • Male
  • Models, Genetic
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Repetitive Sequences, Nucleic Acid / genetics*
  • Repressor Proteins*
  • Transcription Factors / genetics*
  • X Chromosome / genetics
  • Y Chromosome / genetics*


  • DNA-Binding Proteins
  • Drosophila Proteins
  • Kr protein, Drosophila
  • Kruppel-Like Transcription Factors
  • RNA, Messenger
  • Repressor Proteins
  • Transcription Factors