Opposing actions of protein kinase A and C mediate Hebbian synaptic plasticity

Nat Neurosci. 2001 Sep;4(9):871-2. doi: 10.1038/nn0901-871.


A compartmental nerve-muscle tissue culture system expresses Hebbian activity-dependent synapse modulation. Protein kinase C (PKC) mediates a heterosynaptic loss of efficacy, and we now show that protein kinase A (PKA) is involved in homosynaptic stabilization. Both work through postsynaptic changes in the acetylcholine receptor (AChR) as measured electrophysiologically and by imaging techniques.

MeSH terms

  • Cyclic AMP-Dependent Protein Kinases / physiology*
  • Electric Stimulation
  • Enzyme Activation
  • Models, Neurological*
  • Neuronal Plasticity / physiology*
  • Protein Kinase C / physiology*
  • Synapses / physiology*
  • Tetradecanoylphorbol Acetate / pharmacology


  • Cyclic AMP-Dependent Protein Kinases
  • Protein Kinase C
  • Tetradecanoylphorbol Acetate