Spontaneous Remission in a Secondary Acute Myelogenous Leukaemia Following Invasive Pulmonary Aspergillosis

Ann Hematol. 2001 Jul;80(7):423-5. doi: 10.1007/s002770100300.


Spontaneous remission of adult acute myelogenous leukaemia (AML) represents a rare event. We report a 60-year-old female patient suffering from secondary AML M1 and severe invasive pulmonary hyalohyphomycosis highly suggestive of aspergillosis. Two months after the diagnosis of leukaemia, she achieved a spontaneous remission lasting 3 months, although neither cytostatic drugs nor corticoids were administered because of a septic condition. At the time of remission, a chronic hepatitis C virus infection and a polyclonal hypergammaglobulinaemia were present, and the patient received granulocyte colony-stimulating factor once. This report represents the first documentation of a spontaneous remission in AML following invasive pulmonary hyalohyphomycosis. Possible mechanisms of this phenomenon are discussed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillosis / complications*
  • Bone Marrow / pathology
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / microbiology
  • Leukemia, Myeloid, Acute / pathology
  • Leukemia, Myeloid, Acute / physiopathology*
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Diseases, Fungal / complications*
  • Middle Aged
  • Remission, Spontaneous
  • Tomography, X-Ray Computed