Brainstem size and function at term age in relation to later neurosensory disability in high-risk, preterm infants

Acta Paediatr. 2001 Aug;90(8):909-15.


The aim of this study was to measure brainstem size on magnetic resonance imaging (MRI) scans of high-risk. preterm infants, to assess brainstem function by brainstem auditory-evoked potentials (BAEP) and to determine the predictive value of these measures for the neurosensory outcome. A total of 51 preterm infants (gestational age <34 wk, birthweight <1,500 g) underwent examinations at term age; neuromotor outcome and hearing were followed up until a corrected age of 18 mo. Fourteen (27%) infants had neurosensory disability. Those with a later neurosensory disability had a significantly smaller brain stem than those with a normal outcome. The preterm infants had significantly longer peak latency (L) V and interpeak latency (IPL) III-V than the full-term control infants. Most of the preterm infants with severe cerebral palsy or hearing loss had abnormal BAEP. Sensitivity of morphometric dimensions for predicting neurosensory disability was only 20-31%, but specificity was 97-100%. Abnormal L I and IPL III-V in BAEP predicted disability with a sensitivity of 93% and a specificity of 57-59%.

Conclusion: We conclude that adverse events during the perinatal period may lead to morphofunctional changes in the brain stem in high-risk, preterm infants, and it seems that functional changes are accurate in predicting neurosensory disability in such patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Stem / pathology*
  • Brain Stem / physiopathology
  • Cerebral Palsy / diagnosis*
  • Cerebral Palsy / etiology
  • Cohort Studies
  • Deafness / diagnosis*
  • Deafness / etiology
  • Evoked Potentials, Auditory, Brain Stem*
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Infant, Premature* / physiology
  • Magnetic Resonance Imaging / methods
  • Male
  • Sensitivity and Specificity