Synthesis of (+)-galiellalactone. Absolute Configuration of Galiellalactone

Org Lett. 2001 Sep 6;3(18):2843-5. doi: 10.1021/ol016286+.

Abstract

[reaction: see text]. (+)-Galiellalactone was synthesized starting from (R)-(+)-pulegone. Natural and synthetic galiellalactone have opposite optical rotations, demonstrating that the structure of the natural product is 1a.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Interleukin-6 / antagonists & inhibitors
  • Lactones / chemical synthesis*
  • Lactones / chemistry
  • Lactones / pharmacology
  • Molecular Conformation
  • Signal Transduction / drug effects
  • Tumor Cells, Cultured

Substances

  • Interleukin-6
  • Lactones
  • galiellalactone