Transforming growth factor beta, pleiotropic regulator of hematopoietic stem cells: potential physiological and clinical relevance

Int J Hematol. 2001 Jul;74(1):18-25. doi: 10.1007/BF02982545.


Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodifferentiative or antidifferentiative. TGF-beta is the major regulator of stem cell quiescence and can act directly or indirectly through effects on the marrow microenvironment. In addition, paracrine and autocrine actions of TGF-beta have overlapping but distinct regulatory effects on hematopoietic stem/progenitor cells. Neutralization of autocrine TGF-beta has therapeutic potential.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autocrine Communication
  • Cell Division / drug effects
  • Cells, Cultured / drug effects
  • Drug Synergism
  • Fetal Blood / cytology
  • Genetic Vectors / genetics
  • Hematopoiesis / drug effects
  • Hematopoiesis / physiology
  • Hematopoietic Cell Growth Factors / pharmacology
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / drug effects
  • Hematopoietic Stem Cells / metabolism
  • Humans
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Receptors, Transforming Growth Factor beta / drug effects
  • Receptors, Transforming Growth Factor beta / physiology
  • Retroviridae / genetics
  • Transfection
  • Transforming Growth Factor beta / deficiency
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / pharmacology
  • Transforming Growth Factor beta / physiology*
  • Transplantation, Homologous


  • Hematopoietic Cell Growth Factors
  • Receptors, Transforming Growth Factor beta
  • Transforming Growth Factor beta