Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

Brain Res. 2001 Sep 14;913(1):86-9. doi: 10.1016/s0006-8993(01)02743-3.

Abstract

We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-alpha (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / pharmacology*
  • Axons / drug effects
  • Axons / immunology
  • Axons / pathology
  • Behavior, Animal / drug effects*
  • Behavior, Animal / physiology
  • Disease Models, Animal
  • Female
  • Hyperalgesia / drug therapy
  • Hyperalgesia / metabolism
  • Hyperalgesia / physiopathology
  • Mice
  • Mice, Inbred C57BL
  • Mononeuropathies / drug therapy*
  • Mononeuropathies / immunology
  • Mononeuropathies / pathology
  • Nerve Degeneration / drug therapy
  • Nerve Degeneration / immunology
  • Nerve Degeneration / pathology
  • Neuralgia / drug therapy*
  • Neuralgia / immunology
  • Neuralgia / pathology
  • Pain Threshold / drug effects*
  • Pain Threshold / physiology
  • Sciatic Nerve / drug effects*
  • Sciatic Nerve / pathology
  • Sciatic Nerve / surgery
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Tumor Necrosis Factor-alpha / immunology
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Antibodies
  • Tumor Necrosis Factor-alpha