Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling

Curr Opin Genet Dev. 2001 Oct;11(5):541-6. doi: 10.1016/s0959-437x(00)00230-6.

Abstract

Epithelial organs such as the vertebrate hair control periodic self-renewal by regulating the growth of progenitor cells. Recent studies implicate Sonic hedgehog target gene induction in the growth of multipotent hair follicle epithelium and the development of a variety of hair follicle tumors such as basal cell carcinomas. These studies suggest Sonic hedgehog signaling may regulate progenitor cells in other organs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / metabolism
  • Carrier Proteins
  • Cell Differentiation
  • Epithelium / metabolism
  • Epithelium / pathology
  • Gene Expression Regulation, Developmental
  • Hair Follicle / cytology
  • Hair Follicle / growth & development*
  • Hair Follicle / metabolism*
  • Hair Follicle / pathology
  • Hedgehog Proteins
  • Humans
  • Proteins / metabolism
  • Signal Transduction*
  • Skin Neoplasms / genetics
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology
  • Stem Cells / cytology
  • Stem Cells / metabolism*
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*
  • Transcriptional Activation

Substances

  • Bone Morphogenetic Proteins
  • Carrier Proteins
  • Hedgehog Proteins
  • Proteins
  • SHH protein, human
  • Trans-Activators
  • noggin protein