Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 25 (10), 847-53

A Minor E-selectin Ligand, CD65, Is Critical for Extravascular Infiltration of Acute Myeloid Leukemia Cells

Affiliations
Comparative Study

A Minor E-selectin Ligand, CD65, Is Critical for Extravascular Infiltration of Acute Myeloid Leukemia Cells

M Noguchi et al. Leuk Res.

Abstract

Adhesive ligands on acute myeloid leukemic (AML) blasts may mediate transmigration and extravascular infiltration. In this study, 30 AML samples were examined for expression and density of adhesion antigens. By univariate analysis, four patients with extravascular infiltration showed significantly higher expression of CD2, CD11a, CD11b, CD11c, CD15, CD65, CD86, and HLA-DR as compared with patients without infiltration. These four patients also showed significantly higher density of CD11a, CD11b, CD11c, CD15 and CD65 expression. By multivariate analysis, CD65 expression was the only significant independent risk factor for infiltration, suggesting that this is a critical adhesion molecule for extravascular AML infiltration.

Similar articles

See all similar articles

Cited by 4 PubMed Central articles

Publication types

LinkOut - more resources

Feedback