Time zones: a comparative genetics of circadian clocks

Nat Rev Genet. 2001 Sep;2(9):702-15. doi: 10.1038/35088576.


The circadian clock is a widespread cellular mechanism that underlies diverse rhythmic functions in organisms from bacteria and fungi, to plants and animals. Intense genetic analysis during recent years has uncovered many of the components and molecular mechanisms comprising these clocks. Although autoregulatory genetic networks are a consistent feature in the design of all clocks, the weight of evidence favours their independent evolutionary origins in different kingdoms.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Bacteria / genetics
  • Circadian Rhythm / genetics*
  • Drosophila / genetics
  • Drosophila / physiology*
  • Neurospora / genetics
  • Neurospora / physiology
  • Plants / genetics
  • Transcription Factors / genetics*


  • Transcription Factors