Multidrug permeases and subcellular cholesterol transport

Y A Ioannou

doi:10.1038/35089558

Multidrug permeases and subcellular cholesterol transport

Nat Rev Mol Cell Biol. 2001 Sep;2(9):657-68. doi: 10.1038/35089558.

Author

Y A Ioannou¹

Affiliation

¹ Department of Human Genetics, Box 1498, The Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, New York 10029, USA. yiannis.ioannou@mssm.edu

PMID: 11533723
DOI: 10.1038/35089558

Abstract

Studies of Niemann-Pick C (NPC) and Tangier diseases have led to the identification of the causative genes, NPC1 and ABCA1, respectively. Characterization of their protein products shows that NPC1 and ABCA1 are permeases that belong to two different superfamilies of efflux pumps, which might be important in subcellular lipid and cholesterol transport.

Publication types

Review

MeSH terms

ATP-Binding Cassette Transporters / metabolism
ATP-Binding Cassette Transporters / pharmacology
ATP-Binding Cassette Transporters / physiology
Biological Transport
Cholesterol / metabolism*
Humans
Lipid Metabolism, Inborn Errors / etiology
Membrane Transport Proteins / metabolism
Membrane Transport Proteins / pharmacology*
Membrane Transport Proteins / physiology
Niemann-Pick Diseases / etiology
Subcellular Fractions / chemistry*
Tangier Disease / etiology

Substances

ATP-Binding Cassette Transporters
Membrane Transport Proteins
Cholesterol