ATP synthase--a marvellous rotary engine of the cell

Nat Rev Mol Cell Biol. 2001 Sep;2(9):669-77. doi: 10.1038/35089509.


ATP synthase can be thought of as a complex of two motors--the ATP-driven F1 motor and the proton-driven Fo motor--that rotate in opposite directions. The mechanisms by which rotation and catalysis are coupled in the working enzyme are now being unravelled on a molecular scale.

Publication types

  • Review

MeSH terms

  • Animals
  • Catalytic Domain
  • Humans
  • Models, Molecular
  • Molecular Motor Proteins / chemistry
  • Molecular Motor Proteins / metabolism
  • Molecular Motor Proteins / physiology
  • Protein Conformation
  • Proton-Translocating ATPases / chemistry*
  • Proton-Translocating ATPases / metabolism
  • Proton-Translocating ATPases / physiology*
  • Rotation


  • Molecular Motor Proteins
  • Proton-Translocating ATPases