Re-evaluating centrosome function

Nat Rev Mol Cell Biol. 2001 Sep;2(9):688-98. doi: 10.1038/35089575.


Over the past 100 years, the centrosome has risen in status from an enigmatic organelle, located at the focus of microtubules, to a key player in cell-cycle progression and cellular control. A growing body of evidence indicates that centrosomes might not be essential for spindle assembly, whereas recent data indicate that they might be important for initiating S phase and completing cytokinesis. Molecules that regulate centrosome duplication have been identified, and the expanding list of intriguing centrosome-anchored activities, the functions of which have yet to be determined, promises continued discovery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Centrosome / metabolism
  • Centrosome / physiology*
  • Centrosome / ultrastructure
  • Humans
  • Microtubules / metabolism
  • Microtubules / physiology
  • Microtubules / ultrastructure
  • Neoplasms / etiology
  • Spindle Apparatus / metabolism