[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]

Praxis (Bern 1994). 2001 Aug 16;90(33):1346-9.
[Article in German]


Pityrosporum ovale appears to play an important role in the pathogenesis of dandruff as a symptom of seborrheic dermatitis. Climbazole is an antimycotic agent with a high in vitro and in vivo efficacy against P. ovale. In the presented work we investigated the efficacy and safety of a climbazole 0.65% shampoo on seborrheic dermatitis of 30 volunteers. Subjects were diagnosed as having moderate to severe seborrheic dermatitis of the scalp. After a 1-week washout and a 4-week treatment the clinical evaluation showed a successful reduction of dandruff, skin redness and itching in 80% of the volunteers and a mild improvement in 20% of the volunteers. The cosmetic acceptability was very good by the majority. It is concluded that the formulation tested is effective in the treatment of moderate to severe dandruff.

MeSH terms

  • Adult
  • Dermatitis, Seborrheic / drug therapy*
  • Dermatomycoses / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Hair Preparations*
  • Humans
  • Imidazoles / administration & dosage*
  • Malassezia / drug effects*
  • Male
  • Middle Aged
  • Treatment Outcome


  • Hair Preparations
  • Imidazoles
  • climbazole