Structure-activity relationship studies of isoquinolinone type anticancer agent

S H Cheon; J S Park; J Y Lee; Y N Lee; H Yi; B H Chung; B G Choi; W J Cho; S U Choi; C O Lee

doi:10.1007/BF02975091

Structure-activity relationship studies of isoquinolinone type anticancer agent

Arch Pharm Res. 2001 Aug;24(4):276-80. doi: 10.1007/BF02975091.

Authors

S H Cheon¹, J S Park, J Y Lee, Y N Lee, H Yi, B H Chung, B G Choi, W J Cho, S U Choi, C O Lee

Affiliation

¹ College of Pharmacy, Chonnam National University, Kwangju, Korea. shcheon@chonnam.ac.kr

PMID: 11534756
DOI: 10.1007/BF02975091

Abstract

Substituted isoquinolin-1-ones (1) were synthesized to test their in vitro anticancer activity. 3-Biphenyl-N-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Drug Screening Assays, Antitumor
Humans
Indicators and Reagents
Isoquinolines / chemical synthesis*
Isoquinolines / pharmacology*
Magnetic Resonance Spectroscopy
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Indicators and Reagents
Isoquinolines