Neurocognitive and symptom correlates of self-reported childhood sexual abuse in schizophrenia spectrum disorders

Ann Clin Psychiatry. 2001 Jun;13(2):89-92. doi: 10.1023/a:1016667624487.


This study examined whether self-reported childhood sexual abuse in schizophrenia spectrum disorders is linked with severity of neurocognitive deficits. The Wisconsin Card Sorting Test, California Verbal Learning Test, and select WAIS III subtests were administered to 15 participants with schizophrenia or schizoaffective disorder who had been sexually abused and to 28 participants with no abuse history. Controlling for age and premorbid IQ, a MANCOVA indicated there were group differences (f(9, 31) = 5.53, p < .001). Subsequent ANCOVA indicated that the sexual abuse group performed more poorly on tests of working memory and information processing speed. Childhood sexual abuse is associated with more severe working memory deficits in adults with schizophrenia spectrum disorders.

MeSH terms

  • Brain / physiopathology
  • Child
  • Child Abuse, Sexual / psychology*
  • Child Abuse, Sexual / statistics & numerical data*
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / epidemiology
  • Cognition Disorders / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Psychiatric Status Rating Scales
  • Psychotic Disorders / diagnosis*
  • Psychotic Disorders / epidemiology
  • Schizophrenia / diagnosis*
  • Schizophrenia / epidemiology
  • Severity of Illness Index
  • Surveys and Questionnaires*