If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer

Cell Death Differ. 2001 Jun;8(6):582-7. doi: 10.1038/sj.cdd.4400856.


Recognition of phosphatidylserine (PtdSer) is essential for engulfment of apoptotic cells by mammalian phagocytes. Engagement of a new phosphatidylserine-specific receptor (PtdSerR) appears to be necessary for uptake of apoptotic cells. Many other mammalian receptors have been described to function in the clearance of apoptotic cells. The emerging picture is that many of these receptors may provide the strong adhesion needed to increase the likelihood of contact between the PtdSerR and its phospholipid ligand, which is required for uptake. Furthermore, stimulation of this receptor on different types of phagocytes by apoptotic cells, PtdSer-containing liposomes or an IgM monoclonal anti-PtdSer antibody initiates release of TGFbeta, known to be involved in the anti-inflammatory effects of apoptotic cells. Although highly homologous genes exist in C. elegans and Drosophila melanogaster, their role in engulfment of apoptotic cells remains to be determined.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / metabolism
  • Apoptosis*
  • Humans
  • Invertebrates / cytology
  • Invertebrates / metabolism
  • Jumonji Domain-Containing Histone Demethylases
  • Mammals
  • Phagocytosis*
  • Phosphatidylserines / metabolism*
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*


  • Anti-Inflammatory Agents
  • Phosphatidylserines
  • Receptors, Cell Surface
  • phosphatidylserine receptor
  • JMJD6 protein, human
  • Jumonji Domain-Containing Histone Demethylases