[Study of the formation and the normal and pathological evolution of the eye neural primordium (author's transl)]

Arch Anat Histol Embryol. 1978;61:89-142.
[Article in French]


The analysis of duplicate embryos, cyclops and colobomic fissure defects show that: 1. - optic vesicle and colobomic fissure are inducted by the prechordal plate. The combined inductive influence of prechordal plate and notochord carry eye absence out; 2. - initial failure of the colobomic fissure is always associated with retina folds and produce lens, vitreous and optic nerve anomalies; 3. - colobomic fissure is one indispensable anatomic structure to the optic fiber migration from the retina to the optic pedicle. Retina cutting in 4 days old chick embryos determine the disappearing of the pedicle cells. Contact between the optic fiber and the pedicle cells determine the glial cells differentiation. The colobomic fissure is a very important period of the eye evolution and the eye organisation.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Brain / abnormalities
  • Chick Embryo
  • Chlorambucil / toxicity
  • Cyclophosphamide / toxicity
  • Ducks
  • Ectoderm
  • Eye / embryology*
  • Eye / pathology
  • Eye Abnormalities
  • Mice
  • Optic Nerve / cytology
  • Optic Nerve / embryology
  • Rabbits
  • Swine


  • Chlorambucil
  • Cyclophosphamide