Lower Body Negative Pressure (LBNP) as a Countermeasure for Long Term Spaceflight

Acta Astronaut. Feb-Mar 1995;35(4-5):271-80. doi: 10.1016/0094-5765(95)98732-o.


NASA: The article presents the current status of lower body negative pressure (LBNP) as a countermeasure for preventing orthostatic intolerance after space flight or bed rest. Devices discussed include the Chibis vacuum suit, the Anthrorack device, a collapsible device, and an inflatable device. Two bed rest studies examined the effect of LBNP and exercise on orthostatic tolerance; plasma volume; vasopressin, plasma renin activity, and catecholamines; and side effects.

MeSH terms

  • Adult
  • Baroreflex / physiology
  • Bed Rest
  • Catecholamines / blood
  • Exercise
  • Exercise Therapy
  • Head-Down Tilt
  • Hemodynamics / physiology
  • Humans
  • Hypotension, Orthostatic / etiology
  • Hypotension, Orthostatic / prevention & control*
  • Lower Body Negative Pressure*
  • Plasma Volume / physiology
  • Renin / blood
  • Tilt-Table Test
  • Vasopressins / blood
  • Weightlessness Countermeasures*
  • Weightlessness Simulation*


  • Catecholamines
  • Vasopressins
  • Renin