Model based characterization of microgravity induced alterations of CVS-regulation

J Gravit Physiol. 1998 Jul;5(1):P43-4.


A concept called model individualization is presented. It is used to modify computer based models to reproduce observed individual behavior. During D2-, MIR97- and Neurolab-missions tilt-table and LBNP-experiments were carried out. Physiological data describing the cardiovascular reactions of the astronauts were recorded. The appropriateness of the rheoretical principles is demonstrated with MIR97 tilt-table experiments. Finally the resulting individualized model is investigated to propose hypotheses on probable alterations in the cardiovascular system induced by microgravity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aerospace Medicine / methods
  • Blood Pressure / physiology*
  • Computer Simulation*
  • Evaluation Studies as Topic
  • Heart Rate
  • Humans
  • Hypotension, Orthostatic / etiology
  • Hypotension, Orthostatic / physiopathology*
  • Lower Body Negative Pressure
  • Models, Cardiovascular*
  • Predictive Value of Tests
  • Space Flight*
  • Tilt-Table Test
  • Weightlessness*