Model based classification of cardiovascular response patterns

J Gravit Physiol. 1999 Jul;6(1):P41-2.

Abstract

A comprehensive analysis of cardiovascular control (CVC) patterns with multiple subjects is presented. It became feasible by recent methodological advances. Simple computer models were generated automatically, reproducing only factors of the true model that are relevant to the focus if investigation. These models--named aspect-models--could in turn be used in model individualization, thus reducing the necessary computational amount. The achieved speedup by a factor of more than three thousand and the high numerical stability of the resulting method allows the unsupervised identification of a large body of experimental data. The analysis of tilt table experiments of 18 subjects revealed a remarkable variety of reaction patterns. Closer examination yielded different classes of subjects. Two main groups corresponding to basic types of CVC were observed. Three outliers could be assigned to the specific situation of some subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aerospace Medicine
  • Blood Pressure
  • Cardiac Output
  • Cardiovascular Physiological Phenomena*
  • Heart Rate
  • Humans
  • Hypotension, Orthostatic / classification*
  • Hypotension, Orthostatic / etiology
  • Male
  • Models, Cardiovascular*
  • Myocardial Contraction
  • Neural Networks, Computer*
  • Tilt-Table Test
  • Vascular Resistance
  • Vasoconstriction