[Effects of hypoxia and qigong on urine malondialdehyde, superoxide dismutase and circulating endothelial cell in humans during simulated weightlessness]

Space Med Med Eng (Beijing). 1998 Apr;11(2):136-8.
[Article in Chinese]


Changes of lipid hyperoxidation and amount of circulating endothelial cells under simulated weightlessness and factors that may influence these changes were observed in 3 groups of subjects (5 in each group) exposed to 17d - 6 degrees head down bed rest (HDBR), HD-BR+ hypoxia and HDBR + qigong respectively. The results showed: (1) simple HDBR promotes antioxidation activity and attenuates hyperoxidation of lipids, and hypoxia and have some influence on the former but not on the latter; (2) circulating endothelial cells decreased significantly after simple HDBR for 7 d but recovered to normal when HDBR continued for 17 d. Hypoxia showed no influence on this effect while Qigong alleviated it significantly. It suggests that (1)both hypoxia and Qigong have some influence on the promotion of antioxidation activity but have no influence on the production of oxygen free radicals. (2) Qigong shows some antagonistic effect against the attenuation of circulating endothelial cells by HDBR.

Publication types

  • Comparative Study

MeSH terms

  • Bed Rest
  • Breathing Exercises*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / physiology*
  • Free Radicals
  • Head-Down Tilt
  • Humans
  • Hypoxia
  • Malondialdehyde / metabolism*
  • Malondialdehyde / urine
  • Oxygen
  • Superoxide Dismutase / blood
  • Superoxide Dismutase / metabolism*
  • Weightlessness Simulation*


  • Free Radicals
  • Malondialdehyde
  • Superoxide Dismutase
  • Oxygen