Abstract
A new flavonol glycoside, myricetin 3-O-neohesperidoside (1) was isolated from a cytotoxic MeOH extract of the leaves of Physalis angulata. Compound 1 showed remarkable cytotoxicity in vitro against murine leukemia cell line P-388, epidermoid carcinoma of the nasopharynx KB-16 cells, and lung adenocarcinoma A-549 with ED(50) values of 0.048, 0.50 and 0.55 microg ml(-1), respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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Flavonoids / chemistry
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Flavonoids / pharmacology*
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Glycosides / chemistry
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Glycosides / pharmacology*
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Humans
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Inhibitory Concentration 50
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KB Cells / drug effects
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Mice
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Leaves
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Solanaceae*
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents, Phytogenic
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Flavonoids
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Glycosides
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Plant Extracts
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myricetin 3-O-neohesperidoside