A novel cytotoxic flavonoid glycoside from Physalis angulata

Fitoterapia. 2001 Aug;72(6):676-9. doi: 10.1016/s0367-326x(01)00281-7.

Abstract

A new flavonol glycoside, myricetin 3-O-neohesperidoside (1) was isolated from a cytotoxic MeOH extract of the leaves of Physalis angulata. Compound 1 showed remarkable cytotoxicity in vitro against murine leukemia cell line P-388, epidermoid carcinoma of the nasopharynx KB-16 cells, and lung adenocarcinoma A-549 with ED(50) values of 0.048, 0.50 and 0.55 microg ml(-1), respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Flavonoids / chemistry
  • Flavonoids / pharmacology*
  • Glycosides / chemistry
  • Glycosides / pharmacology*
  • Humans
  • Inhibitory Concentration 50
  • KB Cells / drug effects
  • Mice
  • Phytotherapy*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Leaves
  • Solanaceae*
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents, Phytogenic
  • Flavonoids
  • Glycosides
  • Plant Extracts
  • myricetin 3-O-neohesperidoside