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Review
, 13 (5), 555-62

Anoikis Mechanisms

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Review

Anoikis Mechanisms

S M Frisch et al. Curr Opin Cell Biol.

Abstract

Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.

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