Anoikis mechanisms

Curr Opin Cell Biol. 2001 Oct;13(5):555-62. doi: 10.1016/s0955-0674(00)00251-9.


Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Anoikis*
  • Carrier Proteins / metabolism
  • Cytoskeleton / physiology
  • Fas-Associated Death Domain Protein
  • Growth Substances / physiology
  • Humans
  • Integrins / physiology*
  • MAP Kinase Signaling System
  • Models, Biological
  • Neoplasms / pathology
  • Phosphatidylinositol 3-Kinases / physiology
  • Protein Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-akt
  • Signal Transduction


  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • FADD protein, human
  • Fas-Associated Death Domain Protein
  • Growth Substances
  • Integrins
  • Proto-Oncogene Proteins
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt