Abstract
Two groups have now reported the viability of mice that lack syndecan-4. These mice have wound healing/angiogenesis problems, and fibroblasts from these animals differ in adhesion and migration from normal. This is consistent with recent in vitro data indicating a need for signaling via syndecan-4 for focal adhesion formation, and reports that overexpression of proteins that bind syndecan-4 can modify cell adhesion and migration.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Focal Adhesions / physiology*
-
Integrins / physiology
-
Membrane Glycoproteins / chemistry
-
Membrane Glycoproteins / genetics
-
Membrane Glycoproteins / physiology*
-
Mice
-
Mice, Knockout
-
Models, Biological
-
Neovascularization, Pathologic
-
Protein Structure, Tertiary
-
Proteoglycans / chemistry
-
Proteoglycans / genetics
-
Proteoglycans / physiology*
-
Signal Transduction
-
Syndecan-4
-
Wound Healing
Substances
-
Integrins
-
Membrane Glycoproteins
-
Proteoglycans
-
Sdc4 protein, mouse
-
Syndecan-4