Syndecan-4 and focal adhesion function

Curr Opin Cell Biol. 2001 Oct;13(5):578-83. doi: 10.1016/s0955-0674(00)00254-4.


Two groups have now reported the viability of mice that lack syndecan-4. These mice have wound healing/angiogenesis problems, and fibroblasts from these animals differ in adhesion and migration from normal. This is consistent with recent in vitro data indicating a need for signaling via syndecan-4 for focal adhesion formation, and reports that overexpression of proteins that bind syndecan-4 can modify cell adhesion and migration.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Focal Adhesions / physiology*
  • Integrins / physiology
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / physiology*
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Neovascularization, Pathologic
  • Protein Structure, Tertiary
  • Proteoglycans / chemistry
  • Proteoglycans / genetics
  • Proteoglycans / physiology*
  • Signal Transduction
  • Syndecan-4
  • Wound Healing


  • Integrins
  • Membrane Glycoproteins
  • Proteoglycans
  • Sdc4 protein, mouse
  • Syndecan-4