Regulation of Rho GTPases by p120-catenin

Curr Opin Cell Biol. 2001 Oct;13(5):604-10. doi: 10.1016/s0955-0674(00)00258-1.

Abstract

Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism of action and provide a potential explanation for the metastatic phenotype exhibited in carcinoma cells that have lost E cadherin expression.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cadherins / metabolism
  • Catenins
  • Cell Adhesion Molecules / physiology*
  • Cell Movement
  • Contact Inhibition
  • Models, Biological
  • Neoplasm Metastasis
  • Phosphoproteins / physiology*
  • rho GTP-Binding Proteins / metabolism*

Substances

  • Cadherins
  • Catenins
  • Cell Adhesion Molecules
  • Phosphoproteins
  • delta catenin
  • rho GTP-Binding Proteins