Mapping out the roles of MAP kinases in plant defense

Trends Plant Sci. 2001 Sep;6(9):392-4. doi: 10.1016/s1360-1385(01)02058-1.


Arabidopsis contains 20 MAP kinase genes, but their roles in plant physiology have remained largely unknown because of a lack of mutants. Recent papers from two groups have shed new light on the function of two different MAP kinases. The Arabidopsis MPK4 gene appears to negatively regulate salicylic acid-mediated defense responses and positively regulate jasmonic acid-induced responses. The tobacco SIPK gene (orthologous to Arabidopsis MPK6) appears to positively regulate programmed cell death.

Publication types

  • News
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arabidopsis / enzymology*
  • Arabidopsis / microbiology
  • Arabidopsis / physiology
  • Gene Expression Regulation, Enzymologic / drug effects
  • Gene Expression Regulation, Enzymologic / physiology
  • Gene Expression Regulation, Plant / drug effects
  • Gene Expression Regulation, Plant / physiology
  • MAP Kinase Signaling System
  • Mitogen-Activated Protein Kinases / genetics
  • Mitogen-Activated Protein Kinases / metabolism
  • Mitogen-Activated Protein Kinases / physiology*
  • Mutation
  • Plant Diseases / genetics*
  • Plant Diseases / microbiology
  • Protein Tyrosine Phosphatases / genetics
  • Protein Tyrosine Phosphatases / metabolism
  • Protein Tyrosine Phosphatases / physiology
  • Signal Transduction


  • Mitogen-Activated Protein Kinases
  • Protein Tyrosine Phosphatases