FKBPs: at the crossroads of folding and transduction

Trends Plant Sci. 2001 Sep;6(9):426-31. doi: 10.1016/s1360-1385(01)02044-1.


FK506-binding proteins (FKBPs) belong to the large family of peptidyl-prolyl cis-trans isomerases, which are known to be involved in many cellular processes, such as cell signalling, protein trafficking and transcription. FKBPs associate into protein complexes, although the involvement and precise role of their foldase activity remain to be elucidated. FKBPs represent a large gene family in plants that is involved in growth and development. Disruption of genes encoding FKBPs in plants and animals has underlined the importance of this family of proteins in the regulation of cell division and differentiation.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Adenosine Triphosphatases
  • Animals
  • Apoptosis
  • Arabidopsis / classification
  • Arabidopsis / genetics
  • Arabidopsis / physiology
  • Calmodulin / metabolism
  • Cell Cycle
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Phylogeny
  • Plant Physiological Phenomena*
  • Protein Folding*
  • Protein Transport
  • Signal Transduction
  • Tacrolimus Binding Proteins / genetics
  • Tacrolimus Binding Proteins / physiology*


  • Calmodulin
  • Fungal Proteins
  • Membrane Proteins
  • Adenosine Triphosphatases
  • Tacrolimus Binding Proteins