Biotransformation of 1,8-cineole by human liver microsomes

Nat Prod Lett. 2001;15(1):49-53. doi: 10.1080/10575630108041257.

Abstract

The biotransformation of 1,8-cineole has been investigated by using human liver microsomes. A single oxidized metabolite, 2-exo-hydroxy-1,8-cineole, was isolated. Its formation was investigated under various conditions by changing incubation time, P450 level in liver microsomes, and substrate concentration.

MeSH terms

  • Biotransformation
  • Chromatography, Gas
  • Cyclohexanols / pharmacokinetics*
  • Cytochrome P-450 Enzyme System / metabolism
  • Eucalyptol
  • Humans
  • Hydroxylation
  • Microsomes, Liver / enzymology
  • Microsomes, Liver / metabolism*
  • Monoterpenes*
  • Substrate Specificity
  • Terpenes / pharmacokinetics*

Substances

  • Cyclohexanols
  • Monoterpenes
  • Terpenes
  • Cytochrome P-450 Enzyme System
  • Eucalyptol