Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene

Biochem Biophys Res Commun. 2001 Sep 14;287(1):216-22. doi: 10.1006/bbrc.2001.5535.


The human cellular receptor for group B coxsackieviruses and adenoviruses (HCAR) is a transmembrane glycoprotein which belongs to the immunoglobulin superfamily. We describe alternative splicing of the HCAR-gene and the existence of three exon-skipping splice variants in addition to the originally identified seven exon-encompassing mRNA transcript. Expression of the splice variants theoretically results in truncated proteins, possibly leading to impaired viral binding and/or the occurrence of soluble viral receptors due to the absence of the transmembranous region. Consequently, this could markedly influence the efficacy of an adenovirus subgroup C-mediated gene therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviridae / metabolism
  • Alternative Splicing*
  • Amino Acid Sequence
  • Base Sequence
  • Coxsackie and Adenovirus Receptor-Like Membrane Protein
  • Enterovirus / metabolism
  • HeLa Cells
  • Humans
  • Molecular Sequence Data
  • RNA, Messenger / metabolism
  • Receptors, Virus / genetics*


  • CLMP protein, human
  • Coxsackie and Adenovirus Receptor-Like Membrane Protein
  • RNA, Messenger
  • Receptors, Virus