Detection of HTLV-I proviral DNA in sarcoidosis

Dermatology. 2001;203(1):53-6. doi: 10.1159/000051704.

Abstract

'Sarcoidosis-lymphoma syndrome' is known as an association of sarcoidosis with malignant lymphoma. We report a 56-year-old woman with systemic sarcoidosis who was seropositive for antibody against human T cell lymphoma/leukemia virus type I (HTLV-I). This patient showed integration of HTLV-I proviral DNA within cutaneous sarcoid nodules, but not in peripheral blood mononuclear cells. Neither atypical lymphocytes nor a T cell receptor beta1 gene rearrangement were observed in peripheral blood mononuclear cells or in cutaneous nodules, indicating that the patient did not have a smouldering type of adult T cell lymphoma/leukemia. Detection of integration of HTLV-I proviral DNA in cutaneous sarcoid nodules could suggest that the sarcoid nodules might have been generated as a protective response to chronic stimuli of HTLV-I.

Publication types

  • Case Reports

MeSH terms

  • DNA, Viral / analysis*
  • Female
  • Human T-lymphotropic virus 1 / genetics
  • Human T-lymphotropic virus 1 / isolation & purification*
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / complications
  • Leukemia-Lymphoma, Adult T-Cell / diagnosis
  • Leukemia-Lymphoma, Adult T-Cell / virology*
  • Middle Aged
  • Proviruses / genetics*
  • Proviruses / isolation & purification
  • Sarcoidosis / complications
  • Sarcoidosis / pathology
  • Sarcoidosis / virology*
  • Skin / pathology
  • Skin / virology*
  • Virus Integration*

Substances

  • DNA, Viral