Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys

N D Goncharova; B K Khavinson; B A Lapin

doi:10.1023/a:1017928925177

Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys

Bull Exp Biol Med. 2001 Apr;131(4):394-6. doi: 10.1023/a:1017928925177.

Authors

N D Goncharova¹, B K Khavinson, B A Lapin

Affiliation

¹ Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi. iprim@sochi.net

PMID: 11550036
DOI: 10.1023/a:1017928925177

Abstract

The effect of Epithalon on melatonin and cortisol secretion in female rhesus monkeys of various ages was evaluated by enzyme immunoassay. Epithalon stimulated evening melatonin production and normalized circadian rhythms of cortisol production in old monkeys.

MeSH terms

Aging / drug effects*
Aging / metabolism
Animals
Antioxidants / pharmacology*
Female
Hydrocortisone / biosynthesis*
Macaca mulatta
Melatonin / biosynthesis*
Oligopeptides / pharmacology*

Substances

Antioxidants
Oligopeptides
Melatonin
alanyl-glutamyl-aspartyl-glycine
Hydrocortisone