Phosphoribosylpyrophosphate synthetase and the regulation of phosphoribosylpyrophosphate production in human cells

Prog Nucleic Acid Res Mol Biol. 2001;69:115-48. doi: 10.1016/s0079-6603(01)69046-9.

Abstract

between purine nucleoside diphosphate inhibition and inorganic phosphate (Pi) activation; and intracellular concentration of the PRS1 isoform. The operation of additional determinants of rates of PRPP synthesis in human cells is suggested by: (1) multiple PRS isoforms with distinctive physical and kinetic properties; (2) nearly immediate activation of intracellular PRPP synthesis in response to mitogens, growth-promoters, and increased intracellular Mg2+ concentrations; (3) tissue-specific differences in PRS1 and PRS2 transcript and isoform expression; and (4) reversible association of PRS subunits with one another and/or with PRS-associated proteins (PAPs), as a result of which the catalytic and perhaps regulatory properties of PRS isoforms are modified.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacillus subtilis / enzymology
  • Bacillus subtilis / genetics
  • Humans
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / chemistry
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Models, Biological
  • Molecular Sequence Data
  • Phosphoribosyl Pyrophosphate / biosynthesis*
  • Ribose-Phosphate Pyrophosphokinase / antagonists & inhibitors
  • Ribose-Phosphate Pyrophosphokinase / chemistry
  • Ribose-Phosphate Pyrophosphokinase / genetics
  • Ribose-Phosphate Pyrophosphokinase / metabolism*
  • Sequence Homology, Amino Acid

Substances

  • Isoenzymes
  • Phosphoribosyl Pyrophosphate
  • Ribose-Phosphate Pyrophosphokinase