Antioxidative and antitumor promoting effects of [6]-paradol and its homologs

Mutat Res. 2001 Sep 20;496(1-2):199-206. doi: 10.1016/s1383-5718(01)00221-2.

Abstract

Recently, considerable attention is focused on anti-carcinogenic phytochemicals, particularly those derived from medicinal or edible plants. [6]-Paradol, a pungent phenolic compound present in certain Zingiberaceae plants, is known to have antimicrobial and analgesic activities. The compound has been reported to attenuate promotion of skin carcinogenesis and TPA-induced ear edema in female ICR mice, and to induce apoptosis in cultured human promyelocytic leukemia (HL-60) cells. In this study, we performed several biochemical studies to evaluate and compare the cancer chemopreventive potential of [6]-paradol and its synthetic derivatives. [6]-Paradol and its synthetic nonpungent analog, [6]-dehydroparadol significantly decreased the incidence and the multiplicity of skin tumors initiated by 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA). Topical application of [6]-paradol and its derivatives inhibited TPA-induced ear edema and H(2)O(2) production and myeloperoxidase activity in the dorsal skin of mice. Induction of TPA-induced mouse epidermal ornithine decarboxylase (ODC) activity and H(2)O(2)- and UV-induced formation of oxidized DNA bases in vitro were also attenuated by the above compounds. These results indicate that [6]-paradol and its derivatives possess the cancer chemopreventive potential.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / toxicity
  • Administration, Topical
  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Carcinogens / pharmacology
  • DNA Damage / drug effects
  • Ear, External / drug effects
  • Ear, External / pathology
  • Edema / chemically induced
  • Edema / pathology
  • Edema / prevention & control
  • Epidermis / drug effects
  • Epidermis / enzymology
  • Female
  • Guaiacol / administration & dosage
  • Guaiacol / analogs & derivatives
  • Guaiacol / therapeutic use*
  • Hydrogen Peroxide / metabolism
  • Ketones / administration & dosage
  • Ketones / therapeutic use*
  • Mice
  • Mice, Inbred ICR
  • Ornithine Decarboxylase / biosynthesis
  • Peroxidase / biosynthesis
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / prevention & control*
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Antioxidants
  • Carcinogens
  • Ketones
  • 9,10-Dimethyl-1,2-benzanthracene
  • Guaiacol
  • Hydrogen Peroxide
  • 6-paradol
  • Peroxidase
  • Ornithine Decarboxylase
  • Tetradecanoylphorbol Acetate