CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor

Trends Endocrinol Metab. 2001 Oct;12(8):366-70. doi: 10.1016/s1043-2760(01)00454-4.


Cyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. Recently, we identified a novel mammalian source of cAMP - soluble adenylyl cyclase (sAC) - that is regulated directly by bicarbonate ions (HCO(3)(-)). As the concentration of HCO(3)(-) reflects cellular levels of carbon dioxide (CO(2)), energy-generating metabolic processes (which increase intracellular CO(2)) are poised to activate bicarbonate-responsive sAC. This direct link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved mechanism of metabolic feedback regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenylyl Cyclases / metabolism*
  • Animals
  • Bicarbonates / pharmacology*
  • Biological Evolution
  • Carbon Dioxide / metabolism*
  • Cyclic AMP / biosynthesis
  • Homeostasis
  • Hydrogen-Ion Concentration
  • Metabolism*
  • Signal Transduction
  • Solubility


  • Bicarbonates
  • Carbon Dioxide
  • Cyclic AMP
  • Adenylyl Cyclases