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Clinical Trial
, 15 (9), 1499-504

Twenty-minute 50 Mg 13C-urea Breath Test Without Test Meal for the Diagnosis of Helicobacter Pylori Infection in Chinese

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Clinical Trial

Twenty-minute 50 Mg 13C-urea Breath Test Without Test Meal for the Diagnosis of Helicobacter Pylori Infection in Chinese

W M Wong et al. Aliment Pharmacol Ther.

Abstract

Background: We have previously shown that the 75 mg 13C-urea breath test without citrate test meal is highly accurate for the diagnosis of Helicobacter pylori infection in Chinese subjects. A lower dose 50 mg 13C-urea breath test protocol with a sampling time at 20 min has not been validated previously.

Aim: To investigate the accuracy of a 20-min 50 mg 13C-urea breath test protocol in Chinese subjects.

Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-urea breath test was performed using (a) 75 mg and 50 mg of 13C-urea on two separate days without a test meal, and (b) 50 mg of 13C-urea with 2.4 g citrate as test meal, and compared with the gold standard [rapid urease test (CLO test) and histology]. Baseline, 20-min and 30-min breath samples were collected in all cases.

Results: Two hundred and six patients were tested. The accuracy of the 50 mg 13C-urea breath test (no citrate) at 20 min and 30 min was 98%, comparable to that of the 50 mg 13C-urea breath test with citrate (99.1%) and the 75 mg 13C-urea breath test without citrate (100%).

Conclusions: A 20-min 50 mg 13C-urea breath test without citrate produced highly accurate results for the diagnosis of Helicobacter pylori infection and is more economical and convenient for the Chinese population.

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