Differential diagnosis of ovarian tumors based primarily on their patterns and cell types

Semin Diagn Pathol. 2001 Aug;18(3):161-235.


The differential diagnosis of ovarian tumors is reviewed based on their patterns and cell types. This approach, which differs from the standard textbook discussion of each neoplasm as an entity, has practical value as differential diagnosis depends largely on the pattern or patterns and cell type or types of tumors. Awareness of the broad range of lesions that may exhibit particular patterns or contain one or more cell types is crucial in formulating a differential diagnosis. The following patterns are considered: moderate-to-large-glandular and hollow-tubular; solid tubular and pseudotubular; cords and ribbons; insular; trabecular; slit-like and reticular spaces; microglandular and microfollicular; macrofollicular and pseudomacrofollicular; papillary; diffuse; fibromatous-thecomatous; and biphasic and pseudobiphasic. The following cell types are considered: small round cells; spindle cells; mucinous cells, comprising columnar, goblet cell and signet ring cell subtypes; clear cells; hobnail cells; oxyphil cells; and transitional cells. The morphologic diversity of ovarian tumors poses many challenges; knowledge of the occurrence and frequency of these patterns and cell types in various tumors and tumor-like lesions is of paramount diagnostic importance. A specific diagnosis can usually be made by evaluating routinely stained slides, but much less often, special staining, immunohistochemical staining or, very rarely, ultrastructural examination is also required. Finally, clinical data, operative findings, and gross features of the lesions may provide important, and at times decisive diagnostic clues.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / chemistry
  • Adenocarcinoma / classification
  • Adenocarcinoma / diagnosis*
  • Biomarkers, Tumor / analysis
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunohistochemistry
  • Ovarian Neoplasms / chemistry
  • Ovarian Neoplasms / classification
  • Ovarian Neoplasms / diagnosis*
  • Pathology, Clinical / methods


  • Biomarkers, Tumor