Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Aug 24;28(1):17-22.
doi: 10.1007/BF02441213.

Disordered Mineral Metabolism Produced by Ketogenic Diet Therapy

Disordered Mineral Metabolism Produced by Ketogenic Diet Therapy

T J Hahn et al. Calcif Tissue Int. .


Vitamin D and mineral metabolism status was examined in five children maintained chronically on combined ketogenic diet-anticonvulsant drug therapy (KG), and the results compared to those obtained in 18 patients treated with anticonvulsant drugs alone (AD) and 15 normal controls. KG patients exhibited biochemical findings of vitamin D deficiency osteomalacia: decreased serum 25-hydroxyvitamin D (25OHD) and calcium concentrations, elevated serum alkaline phosphatase and parathyroid hormone concentrations, decreased urinary calcium and increased urinary hydroxyproline excretion, and decreased bone mass. Although the KG and AD groups demonstrated similar reductions in serum 25OHD concentration, the KG patients exhibited a significantly greater reduction in bone mass. In response to vitamin D supplementation (5000 IU/day), mean bone mass in the KG group increased by 8.1 +/- 0.9% (P less than 0.001) over a 12-month period. These results suggest that ketogenic diet and anticonvulsant drug therapy have additive deleterious effects on bone mass and that these effects are partially reversible by vitamin D treatment.

Similar articles

See all similar articles

Cited by 10 articles

See all "Cited by" articles


    1. Clin Sci Mol Med. 1974 Apr;46(4):433-48 - PubMed
    1. J Clin Endocrinol Metab. 1974 Aug;39(2):274-82 - PubMed
    1. Br Med J. 1970 Oct 10;4(5727):69-72 - PubMed
    1. Pediatrics. 1975 Jul;56(1):45-50 - PubMed
    1. J Clin Invest. 1971 Mar;50(3):492-9 - PubMed

MeSH terms

LinkOut - more resources