Asymmetric synthesis of (-)-indolizidine 209D via B-alkyl Suzuki coupling and amination reactions

G Kim; S D Jung; W J Kim

doi:10.1021/ol0163171

Asymmetric synthesis of (-)-indolizidine 209D via B-alkyl Suzuki coupling and amination reactions

Org Lett. 2001 Sep 20;3(19):2985-7. doi: 10.1021/ol0163171.

Authors

G Kim¹, S D Jung, W J Kim

Affiliation

¹ Department of Chemistry, College of Natural Science, Chungnam National University, Taejon 305-764, Korea. guncheol@cuvic.cnu.ac.kr

PMID: 11554824
DOI: 10.1021/ol0163171

Abstract

(-)-Indolizidine 209D has been synthesized using consecutive amination reactions of compound 11. The precursor was prepared concisely using B-alkyl Suzuki cross coupling of chiral homoallyl amine and vinyl iodide compounds. Reaction: see text.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemical synthesis*
Amines / chemical synthesis
Animals
Indolizines / chemical synthesis*
Nicotinic Antagonists / chemical synthesis
Ranidae
Stereoisomerism

Substances

Alkaloids
Amines
Indolizines
Nicotinic Antagonists
indolizidine 209D