Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission?

J Med Primatol. 2001 Aug;30(4):190-6. doi: 10.1034/j.1600-0684.2001.d01-52.x.


To develop immunoprophylaxis regimens against mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission, we established a simian-human immunodeficiency virus (SHIV) model in neonatal macaques that mimics intrapartum mucosal virus exposure (T.W. Baba, J. Koch, E.S. Mittler et al: AIDS Res Hum Retroviruses 10:351-357, 1994). We protected four neonates from oral SHIV-vpu+ challenge by ante- and postpartum treatment with a synergistic triple combination of immunoglobulin (Ig) G1 human anti-HIV-1 neutralizing monoclonal antibodies (mAbs) (T.W. Baba, V. Liska, R. Hofmann-Lehmann et al: Nature Med 6:200-206, 2000), which recognize the CD4-binding site of Env, a glycosylation-dependent gp120, or a linear gp41 epitope. Two neonates that received only postpartum mAbs were also protected from oral SHIV-vpu+ challenge, indicating that postpartum treatment alone is sufficient. Next, we evaluated a similar mAb combination against SHIV89.6P, which encodes env of primary HIV89.6. One of four mAb-treated neonates was protected from infection and two maintained normal CD4+ T-cell counts. We conclude that the epitopes recognized by the three mAbs are important determinants for achieving protection. Combination immunoprophylaxis with synergistic mAbs seems promising to prevent maternal HIV-1 transmission in humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / prevention & control
  • Acquired Immunodeficiency Syndrome / transmission*
  • Animals
  • Antibodies, Monoclonal / therapeutic use
  • Chimera
  • Disease Models, Animal
  • Female
  • HIV Infections / prevention & control
  • HIV Infections / transmission*
  • HIV-1 / pathogenicity*
  • Humans
  • Immunization, Passive*
  • Immunoglobulin G / therapeutic use
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical / prevention & control*
  • Macaca mulatta
  • Male
  • Postpartum Period
  • Pregnancy
  • Simian Immunodeficiency Virus / physiology*


  • Antibodies, Monoclonal
  • Immunoglobulin G