Lymphatic filariasis: an infection of childhood

Trop Med Int Health. 2001 Aug;6(8):582-606. doi: 10.1046/j.1365-3156.2001.00765.x.


Lymphatic filariasis (LF), already recognized as a widespread, seriously handicapping disease of adults, was generally thought to occur only sporadically in children. New, highly sensitive diagnostic tests (antigen detection, ultrasound examination) now reveal, however, that LF is first acquired in childhood, often with as many as one-third of children infected before age 5. Initial damage to the lymphatic system by the parasites generally remains subclinical for years or gives rise only to non-specific presentations of adenitis/adenopathy; however, especially after puberty the characteristic clinical features of the adult disease syndromes (lymphoedema, hydrocoele) manifest themselves. Recognizing that LF disease starts its development in childhood has immediate practical implications both for management and prevention of the disease in individual patients and for the broader public health efforts to overcome all childhood illnesses. For the new World Health Organization (WHO)-supported, public-/private-sector collaboration (Global Alliance) to eliminate LF through once-yearly drug treatment, this recognition means that children will be not only the principal beneficiaries of LF elimination but also a population particularly important to target in order for the programme to achieve its twin goals of interrupting transmission and preventing disease.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Child
  • Child, Preschool
  • Elephantiasis, Filarial* / diagnosis
  • Elephantiasis, Filarial* / epidemiology
  • Elephantiasis, Filarial* / immunology
  • Elephantiasis, Filarial* / pathology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • Prevalence
  • Sex Distribution