Treatment With tobramycin solution for inhalation in bronchiectasis patients with Pseudomonas aeruginosa

Chest. 2001 Sep;120(3 Suppl):114S-117S. doi: 10.1378/chest.120.3_suppl.114s.


A randomized, placebo-controlled, multicenter trial evaluated the safety and efficacy of 300 mg aerosolized tobramycin solution for inhalation (TSI) administered twice daily for 4 weeks in 74 bronchiectasis patients colonized with Pseudomonas aeruginosa (PA). Patients were evenly divided between TSI therapy and placebo. After 2 weeks of treatment, patients treated with TSI had a mean reduction in sputum PA density of 4.8 log(10.) This reduction was maintained for the duration of treatment. The placebo group showed no change in PA density during the study. Two weeks after the end of therapy, PA had been eradicated in 13 TSI-treated patients. PA was not eradicated in any placebo patients. Among those colonized with Staphylococcus aureus at baseline, 6 of 9 patients in the TSI group and 2 of 9 patients in the placebo group were culture negative for this organism 2 weeks posttreatment. Sixty-two percent of TSI-treated patients were judged by a physician as having an improved general health status, compared with 38% of placebo-treated patients. Dyspnea, wheezing, and chest tightness were reported more frequently in the TSI-treated patient group than in the placebo-treated patient group.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aerosols
  • Bronchiectasis / drug therapy*
  • Bronchiectasis / microbiology
  • Colony Count, Microbial
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Forced Expiratory Volume / drug effects
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Nebulizers and Vaporizers*
  • Pseudomonas Infections / drug therapy*
  • Pseudomonas Infections / microbiology
  • Sputum / microbiology
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology
  • Tobramycin / administration & dosage*
  • Tobramycin / adverse effects
  • Treatment Outcome
  • Vital Capacity / drug effects


  • Aerosols
  • Tobramycin