Potential mechanisms of adverse pulmonary and cardiovascular effects of particulate air pollution (PM10)

Int J Hyg Environ Health. 2001 Jul;203(5-6):411-5. doi: 10.1078/1438-4639-00059.


PM10 is the international convention for measuring environmental particulate air pollution. Increases in PM10 have been linked to exacerbations of airways disease and deaths from respiratory and cardiovascular causes. PM10 is a complex and variable mixture but toxicological data suggests that ultrafine particles, transition metals and endotoxins are the most likely components to mediate adverse health effects. Potential mechanisms for the local and systemic adverse effects of PM10 are discussed.

Publication types

  • Review

MeSH terms

  • Air Pollutants / adverse effects*
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / physiopathology*
  • Endotoxins / adverse effects
  • Humans
  • Metals, Heavy / adverse effects
  • Particle Size
  • Respiratory Tract Diseases / etiology
  • Respiratory Tract Diseases / physiopathology*


  • Air Pollutants
  • Endotoxins
  • Metals, Heavy