Antimalarial drugs clear resistant parasites from partially immune hosts

P Cravo; R Culleton; P Hunt; D Walliker; M J Mackinnon

doi:10.1128/AAC.45.10.2897-2901.2001

Antimalarial drugs clear resistant parasites from partially immune hosts

Antimicrob Agents Chemother. 2001 Oct;45(10):2897-901. doi: 10.1128/AAC.45.10.2897-2901.2001.

Authors

P Cravo¹, R Culleton, P Hunt, D Walliker, M J Mackinnon

Affiliation

¹ Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Rd., Edinburgh EH9 3JT, United Kingdom.

Abstract

Circumstantial evidence in human malaria suggests that elimination of parasites by drug treatment meets higher success rates in individuals having some background immunity. In this study, using the rodent malaria model Plasmodium chabaudi, we show that drug-resistant parasites can be cleared by drugs when the host is partially immune.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / therapeutic use*
Chloroquine / therapeutic use
Disease Models, Animal
Drug Resistance
Immunization
Malaria / drug therapy*
Malaria / immunology
Malaria / parasitology
Mefloquine / therapeutic use
Mice
Plasmodium chabaudi* / drug effects

Substances

Antimalarials
Chloroquine
Mefloquine