Peroxisome proliferator-activated receptors in endothelial cell biology

Curr Opin Lipidol. 2001 Oct;12(5):511-8. doi: 10.1097/00041433-200110000-00006.

Abstract

New insights into the endothelium as a dynamic, interactive organ have generated increased interest in endothelial cell transcriptional regulation. Peroxisomal proliferator-activated receptors (PPARs), as ligand-activated nuclear receptors expressed in endothelial cells, represent one important pathway that likely influences vascular responses both directly and indirectly by altering gene expression. PPAR ligands such as fibrates (PPAR-alpha) and insulin-sensitizing thiazolidinediones (PPAR-gamma) are in clinical use and may alter the process of atherosclerosis. The present review highlights the emerging evidence for PPAR-alpha and PPAR-gamma expression in the vasculature, as well as their potential roles in endothelial cell biology.

Publication types

  • Review

MeSH terms

  • Adipocytes / drug effects
  • Adipocytes / physiology
  • Animals
  • Arteriosclerosis / physiopathology*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / physiology*
  • Gene Expression Regulation / drug effects*
  • Gene Expression Regulation / physiology
  • Humans
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Transcription Factors / pharmacology
  • Transcription Factors / physiology*

Substances

  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors