Effect of Lepidium meyenii (maca) roots on spermatogenesis of male rats

Asian J Androl. 2001 Sep;3(3):231-3.


Aim: To determine the effect of oral administration of an aqueous extract from the roots of Lepidium meyenii (maca) on spermatogenesis in adult male rats.

Methods: Male rats received an aqueous extract of the root (66.7 mg in one mL) twice a day for 14 consecutive days.

Results: Treatment with Lepidium meyenii resulted in an increase in the weights of testis and epididymis but not the seminal vesicle weight. The length and frequency of stages IX-XIV seminiferous tubules, where mitosis occurred, were increased and stages I-VI were reduced in rats treated with Lepidium meyenii.

Conclusion: The Lepidium meyenii root invigorates spermatogenesis in male rats by acting on its initial stages (IX-XIV).

MeSH terms

  • Administration, Oral
  • Animals
  • Lepidium*
  • Male
  • Organ Size
  • Plant Preparations / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Seminiferous Epithelium / anatomy & histology
  • Seminiferous Epithelium / drug effects
  • Spermatogenesis / drug effects*


  • Plant Preparations