A cyclobutane carbonucleoside with marked selectivity against TK+ and TK- varicella zoster virus

C López; C Balo; J M Blanco; F Fernández; E De Clercq; J Balzarini

doi:10.1081/NCN-100002505

A cyclobutane carbonucleoside with marked selectivity against TK+ and TK- varicella zoster virus

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1133-5. doi: 10.1081/NCN-100002505.

Authors

C López¹, C Balo, J M Blanco, F Fernández, E De Clercq, J Balzarini

Affiliation

¹ Dpto. Química Orgánica, Universidade de Santiago, E-15706, Santiago de Compostela, Spain.

PMID: 11562972
DOI: 10.1081/NCN-100002505

Abstract

Several cyclobutyladenine and analogous carbonucleosides were synthesized from 1R-alpha-pinene and their anti-viral activity was tested. One of them (3e) showed interesting selectivity against both TK+ and TK- VZV.

MeSH terms

Antiviral Agents / chemical synthesis
Antiviral Agents / pharmacology*
Cyclobutanes / chemical synthesis
Cyclobutanes / pharmacology*
Herpesvirus 3, Human / drug effects*
Herpesvirus 3, Human / enzymology
Microbial Sensitivity Tests
Nucleosides / chemical synthesis
Nucleosides / pharmacology*

Substances

Antiviral Agents
Cyclobutanes
Nucleosides