6-azacytidine--compound with wide spectrum of antiviral activity

I Alexeeva; N Dyachenko; L Nosach; V Zhovnovataya; S Rybalko; R Lozitskaya; A Fedchuk; V Lozitsky; T Gridina; A Shalamay; L Palchikovskaja; O Povnitsa

doi:10.1081/NCN-100002508

6-azacytidine--compound with wide spectrum of antiviral activity

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1147-52. doi: 10.1081/NCN-100002508.

Authors

I Alexeeva¹, N Dyachenko, L Nosach, V Zhovnovataya, S Rybalko, R Lozitskaya, A Fedchuk, V Lozitsky, T Gridina, A Shalamay, L Palchikovskaja, O Povnitsa

Affiliation

¹ Institute of Molecular Biology and Genetics, Kyiv, Ukraine.

PMID: 11562975
DOI: 10.1081/NCN-100002508

Abstract

6-azacytidine demonstrates activity against adenoviruses types 1, 2, 5. It inhibit synthesis of viral DNA and proteins. 6-AC shows antiherpetic and antiinfluenza action during experimental infection in mice. 6-AC is prospective for drug development as an antiviral substance with a wide spectrum of activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / pharmacology*
Azacitidine / analogs & derivatives
Azacitidine / pharmacology*
Disease Models, Animal
Dose-Response Relationship, Drug
Encephalitis, Herpes Simplex / drug therapy
HeLa Cells
Herpes Simplex / drug therapy
Herpesvirus 1, Human / drug effects
Humans
Influenza A virus / drug effects
Influenza, Human / drug therapy
Mice

Substances

Antiviral Agents
Azacitidine
6-azacytidine