Specific binding and stabilization of DNA and phosphorothioate DNA by amphiphilic alpha-helical peptides

Nucleosides Nucleotides Nucleic Acids. Apr-Jul 2001;20(4-7):1313-6. doi: 10.1081/NCN-100002544.

Abstract

Synthetic cationic peptides with amphiphilic alpha-helical structure were found to have DNA binding ability to stabilize double and triple stranded DNA. The stabilization effect was significant for cationic alpha-helical peptides indicating the importance of an electrostatic interaction of a positive charge of peptides and a negative charge of DNAs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Cations
  • DNA / chemistry*
  • Drug Stability
  • Molecular Sequence Data
  • Oligonucleotides / chemistry
  • Oligopeptides / chemistry*
  • Phosphates / chemistry*
  • Protein Structure, Secondary
  • Substrate Specificity

Substances

  • Cations
  • Oligonucleotides
  • Oligopeptides
  • Phosphates
  • triplex DNA
  • phosphorodithioic acid
  • DNA